230nm波长的UVCLED光也对人体无害？Is 230nm UVLED light harmless to human body?

在德国，每年发生40万至60万例医院细菌感染-约有10,000至20,000人死亡。由于多药耐药（MDR）病原体通常无法用抗生素治疗，因此需要其他方法。一种有前途的物理原理是用UVC光照射，可用于破坏微生物而不会产生抗性。

In Germany, between 400000 and 600000 hospital bacterial infections occur each year - about 10000 to 20000 people die. Since multidrug-resistant (MDR) pathogens are usually not treated with antibiotics, other methods are needed. One promising physical principle is that UVC light irradiation can be used to destroy microorganisms without producing resistance.

氮化镓光电联合实验室，费迪南德·布劳恩研究所（FBH）和柏林工业大学（TUB）共同开发了在远紫外光谱范围内发射的AlGaN LED。LED发射的波长约为230 nm，并提供超过1毫瓦的输出功率。

AlGaN LED emitting in the far ultraviolet spectrum has been developed by the Joint Laboratory of Gan optoelectronics, the Ferdinand Braun Institute (FBH) and the Berlin University of Technology (tub). LEDs emit wavelengths of about 230 nm and provide an output power of more than 1 MW.

Ferdinand-Braun-Institut研发的新型LED照射系统旨在通过超短波紫外线杀死微生物-无副作用

Ferdinand Braun Institut's new LED irradiation system aims to kill microorganisms through ultra short wave ultraviolet radiation - no side effects

与汞蒸气灯发出的长波UVC辐射不同，230nm的紫外光不会穿透皮肤的生命层。因此，希望它可以在没有任何损害的情况下使用，也可以将其自然修复的损害降至最低。研究人员希望这将有助于杀死MDR病原体，而没有任何长期的副作用。

Unlike the long wave UVC radiation emitted by mercury vapor lamp, 230 nm ultraviolet light does not penetrate the life layer of skin. Therefore, it is hoped that it can be used without any damage, and the damage of natural repair can be minimized. The researchers hope this will help kill the MDR pathogen without any long-term side effects.

在VIMRE项目（通过体内UVC辐射预防多药耐药病原体感染）的框架内，FBH开发并生产了一种辐射系统，该辐射系统在8 cm x 8 cm的区域上包含118个这些LED的阵列。它在6 cm x 6 cm的区域内实现了0.2 mW / cm2的最大照射功率，且90％以上的均匀度。

Within the framework of the vimre project (prevention of multidrug-resistant pathogen infections through in vivo UVC radiation), FBH has developed and produced a radiation system containing 118 arrays of these LEDs in an area of 8 cm x 8 cm. It achieves a maximum irradiation power of 0.2 MW / cm2 in the region of 6 cm x 6 cm, and the uniformity is more than 90%.

第一台原型机已交付给柏林夏利特大学Charité皮肤科进行皮肤检查。另一台设备将很快交付给格赖夫斯瓦尔德大学医学中心的卫生与环境医学研究所，以阐明其杀菌效果。VIMRE由德国联邦教育和研究部（BMBF）资助，是“Advanced UV for Life”计划的一部分。

The first prototype has been delivered to the charit é dermatology department of Charlet University in Berlin for skin examination. Another device will soon be delivered to the Institute of health and environmental medicine at the medical center of Griffith Wald university to clarify its germicidal efficacy. Vimre is funded by the German Federal Ministry of education and Research (BMBF) and is part of the "advanced UV for life" program.

两个项目合作伙伴使用这些设备进行的测试旨在表明UVC辐射适合杀死微生物，尤其是MDR病原体（根除）。同时，要证明，只要保持特定的辐射剂量，这种接触对人类是无害的。这将使用人体皮肤的组织样本以及皮肤和粘膜模型进行验证，因为微生物（例如MDR病原体）的首选栖息地是前鼻腔和咽部。为此，Charité进行了剂量依赖性研究，以研究可能对辐照皮肤造成的DNA损伤。

Tests conducted by two project partners using these devices were designed to demonstrate that UVC radiation is suitable for killing microorganisms, especially MDR pathogens (eradication). At the same time, it should be proved that such exposure is harmless to humans as long as a certain radiation dose is maintained. This will be validated using tissue samples of human skin as well as skin and mucous membrane models, as the preferred habitat for microorganisms such as MDR pathogens is the anterior nasal cavity and pharynx. To this end, charit é conducted a dose-dependent study to investigate possible DNA damage to irradiated skin.

格赖夫斯瓦尔德大学医学中心将确定UV LED发射器如何有效杀死230 nm的MDR病原体，并将其结果与254 nm和222 nm的UV灯的结果进行比较。

Griffwald University Medical Center will determine how UV LED emitters can effectively kill MDR pathogens at 230 nm and compare the results with those of 254 nm and 222 nm UV lamps.